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Drawing on experience and international research this guide, published by the Higher Education Research and Development Society of Australasia, provides theoretical and practical models to design, embed and evaluate interprofessional education. The guide includes practical advice on leadership of interprofessional education, planning interprofessional curricula, designing, assessing and evaluating interprofessional learning experiences, professional development for staff facilitating interprofessional education and case studies from Australia, New Zealand and other parts of the globe. Whilst based on interprofessional education in health, the guide will be relevant to all academics with an interest in building collaborative, cross or interdisciplinary capabilities in their students.