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This presentation (46:03 minutes) given by Mark Dewey discusses polypharmacy and medication deprescribing in older adults. By the end of this lecture, learners should be able to: (1) describe the difference between a side effect, adverse drug reaction, and adverse event; (2) describe general types of adverse drug reactions; (3) describe procedures for identifying adverse drug reactions; and (4) describe interventions to help minimize polypharmacy and adverse drug events.