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Interprofessional education (IPE) began as a health and social care movement in the early 1970s and took firm hold in US-based accreditation standards in the mid-2000s. IPE should start early in health professions education and prepare clinicians for cross-disciplinary work culture that nourishes quality, collegiality, and safety in a rapidly evolving health sector. Since formation of the Interprofessional Education Collaborative®, IPE trends have gained momentum. This theme issue considers strategies for wider implementation of educational innovations that promote patient-centered and collaborative care, reduce iatrogenic harm, and improve health outcomes.